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1

The importance of plasma protein binding in drug discovery

Trainor, George L

Journal:

Expert Opinion on Drug Discovery

Year:

2007

Language:

english

File:

PDF, 208 KB

english, 2007

2

Discovery and Optimization of Novel Pyrazolopyrimidines as Potent and Orally Bioavailable Allosteric HIV-1 Integrase Inhibitors

Li, Guo, Meanwell, Nicholas A., Krystal, Mark R., Langley, David R., Naidu, B. Narasimhulu, Sivaprakasam, Prasanna, Lewis, Hal, Kish, Kevin, Khan, Javed A., Ng, Alicia, Trainor, George L., Cianci, Chr

Journal:

Journal of Medicinal Chemistry

Year:

2020

Language:

english

File:

PDF, 3.60 MB

english, 2020

3

Preparation and structure-activity relationships of simplified analogs of the antifungal agent cilofungin: a total synthesis approach

Zambias, Robert A., Hammond, Milton L., Heck, James V., Bartizal, Ken, Trainor, Charlotte, Abruzzo, George, Schmatz, Dennis M., Nollstadt, Karl M.

Journal:

Journal of Medicinal Chemistry

Year:

1992

Language:

english

File:

PDF, 1.73 MB

english, 1992

4

Book reviews

Zahedieh, Nuala, Williams, Glyndwr, Marshall, P.J., Rich, Paul B., Shaw, A.G.L., Trainor, Luke, Latham, Martin, Shepperson, George, Stevenson, David, Ballhatchet, Kenneth, Dilks, David N., Millar, T.B

Journal:

The Journal of Imperial & Commonwealth History

Year:

1988

Language:

english

File:

PDF, 1.32 MB

english, 1988

5

ChemInform Abstract: Thiazolo[4,5-d]pyrimidine Thiones and -ones as Corticotropin-Releasing Hormone (CRH-R1) Receptor Antagonists.

James P. Beck, Matt A. Curry, Robert J. Chorvat, Larry W. Fitzgerald, Paul J. Gilligan, Robert Zaczek, George L. Trainor

Journal:

Year:

1999

File:

PDF, 33 KB

1999

6

ChemInform Abstract: Purin-8-ones as Corticotropin-Releasing Hormone (CRH-R1) Receptor Antagonists.

James P. Beck, Argyrios G. Arvanitis, Matt A. Curry, Joseph T. Rescinito, Larry W. Fitzgerald, Paul J. Gilligan, Robert Zaczek, George L. Trainor

Journal:

Year:

1999

File:

PDF, 30 KB

1999

7

ChemInform Abstract: Synthesis and Evaluation of Benzoxazinones as HIV-1 Reverse Transcriptase Inhibitors. Analogues of Efavirenz (Sustiva).

Mona Patel, Robert J. McHugh Jr., Beverly C. Cordova, Ronald M. Klabe, Susan Erickson-Viitanen, George L. Trainor, Soo S. Ko

Journal:

Year:

2000

File:

PDF, 36 KB

2000

8

ChemInform Abstract: Cyclin-Dependent Kinase Inhibitors: Useful Targets in Cell Cycle Regulation

Thais M. Sielecki, John F. Boylan, Pamela A. Benfield, George L. Trainor

Journal:

Year:

2000

File:

PDF, 26 KB

2000

9

ChemInform Abstract: Synthesis and Evaluation of Quinoxalinones as HIV-1 Reverse Transcriptase Inhibitors.

Mona Patel, Robert J. McHugh Jr., Beverly C. Cordova, Ronald M. Klabe, Susan Erickson-Viitanen, George L. Trainor, James D. Rodgers

Journal:

Year:

2000

File:

PDF, 35 KB

2000

10

ChemInform Abstract: Synthesis and Evaluation of Efavirenz (Sustiva) Analogues as HIV-1 Reverse Transcriptase Inhibitors: Replacement of the Cyclopropylacetylene Side Chain.

Anthony J. Cocuzza, Dennis R. Chidester, Beverly C. Cordova, Susan Jeffrey, Rodney L. Parsons, Lee T. Bacheler, Susan Erickson-Viitanen, George L. Trainor, Soo S. Ko

Journal:

Year:

2001

Language:

english

File:

PDF, 34 KB

english, 2001

11

Cost of treatment of congenital dislocation of the hip

George Kernohan, Bernadette Trainor, Raymond Mollan, Charles Normand

Journal:

The International Journal of Health Planning and Management

Year:

1991

Language:

english

File:

PDF, 242 KB

english, 1991

12

Inorganic Ligand Effects on Pb(II) Sorption to Goethite (α-FeOOH): I. Carbonate

John D. Ostergren, Thomas P. Trainor, John R. Bargar, Gordon E. Brown Jr., George A. Parks

Journal:

Journal of Colloid and Interface Science

Year:

2000

Language:

english

File:

PDF, 408 KB

english, 2000

13

Adsorption and Precipitation of Aqueous Zn(II) on Alumina Powders

Thomas P. Trainor, Gordon E. Brown Jr., George A. Parks

Journal:

Journal of Colloid and Interface Science

Year:

2000

Language:

english

File:

PDF, 284 KB

english, 2000

14

Chirality transfer to iron in a photochemical reaction of a glucopyranosyliron compound

George L. Trainor

Journal:

Journal of Organometallic Chemistry

Year:

1985

Language:

english

File:

PDF, 213 KB

english, 1985

15

Optimization of pyrazole inhibitors of Coactivator Associated Arginine Methyltransferase 1 (CARM1)

Tram Huynh, Zhong Chen, Suhong Pang, Jieping Geng, Tiziano Bandiera, Simona Bindi, Paola Vianello, Fulvia Roletto, Sandrine Thieffine, Arturo Galvani, Wayne Vaccaro, Michael A. Poss, George L. Trainor

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2009

Language:

english

File:

PDF, 548 KB

english, 2009

16

Synthesis and evaluation of 2-anilino-3-phenylsulfonyl-6-methylpyridines as corticotropin-releasing factor1 receptor ligands

Richard A. Hartz, Argyrios G. Arvanitis, Charles Arnold, Joseph P. Rescinito, Kimberly L. Hung, Ge Zhang, Harvey Wong, David R. Langley, Paul J. Gilligan, George L. Trainor

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 133 KB

english, 2006

17

Identification of 2-amino-5-(thioaryl)thiazoles as inhibitors of nerve growth factor receptor TrkA

Soong-Hoon Kim, John S. Tokarski, Kenneth J. Leavitt, Brian E. Fink, Mark E. Salvati, Robert Moquin, Mary T. Obermeier, George L. Trainor, Gregory G. Vite, Linda K. Stadnick, Jonathan S. Lippy, Dan Yo

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 289 KB

english, 2008

18

Benzo[d]imidazole inhibitors of Coactivator Associated Arginine Methyltransferase 1 (CARM1)—Hit to Lead studies

Honghe Wan, Tram Huynh, Suhong Pang, Jieping Geng, Wayne Vaccaro, Michael A. Poss, George L. Trainor, Matthew V. Lorenzi, Marco Gottardis, Lata Jayaraman, Ashok V. Purandare

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2009

Language:

english

File:

PDF, 1.02 MB

english, 2009

19

Synthesis and evaluation of quinoxalinones as HIV-1 reverse transcriptase inhibitors

Mona Patel, Robert J McHugh Jr., Beverly C Cordova, Ronald M Klabe, Susan Erickson-Viitanen, George L Trainor, James D Rodgers

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2000

Language:

english

File:

PDF, 132 KB

english, 2000

20

Synthesis and Evaluation of Efavirenz (SustivaTM) Analogues as HIV-1 Reverse Transcriptase Inhibitors: Replacement of the Cyclopropylacetylene Side Chain

Anthony J. Cocuzza, Dennis R. Chidester, Beverly C. Cordova, Susan Jeffrey, Rodney L. Parsons, Lee T. Bacheler, Susan Erickson-Viitanen, George L. Trainor, Soo S. Ko

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 102 KB

english, 2001

21

The synthesis and antitumor evaluation of unsymmetrical bis-imides

Robert J. Cherney, Stephen G. Swartz, Arthur D. Patten, Emeka Akamike, Jung-Hui Sun, Robert F. Kaltenbach III, Steven P. Seitz, Carl H. Behrens, Zelleka Getahun, George L. Trainor, Mike Vavala, Mindy

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1997

Language:

english

File:

PDF, 272 KB

english, 1997

22

Purin-8-ones as corticotropin-releasing hormone (CRH-R1) receptor antagonists

James P. Beck, Argyrios G. Arvanitis, Matt A. Curry, Joseph T. Rescinito, Larry W. Fitzgerald, Paul J. Gilligan, Robert Zaczek, George L. Trainor

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1999

Language:

english

File:

PDF, 300 KB

english, 1999

23

Thiazolo[4,5-d]pyrimidine thiones and -ones as corticotropin-releasing hormone (CRH-R1) receptor antagonists

James P. Beck, Matt A. Curry, Robert J. Chorvat, Larry W. Fitzgerald, Paul J. Gilligan, Robert Zaczek, George L. Trainor

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1999

Language:

english

File:

PDF, 219 KB

english, 1999

24

Synthesis and evaluation of analogs of Efavirenz (SUSTIVATM) as HIV-1 reverse transcriptase inhibitors

Mona Patel, Soo S. Ko, Robert J. McHugh Jr., Jay A. Markwalder, Anurag S. Srivastava, Beverly C. Cordova, Ronald M. Klabe, Susan Erickson-Viitanen, George L. Trainor, Steven.P. Seitz

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1999

Language:

english

File:

PDF, 279 KB

english, 1999

25

Synthesis and evaluation of benzoxazinones as HIV-1 reverse transcriptase inhibitors. Analogs of Efavirenz (SUSTIVATM)

Mona Patel, Robert J. McHugh Jr., Beverly C. Cordova, Ronald M. Klabe, Susan Erickson-Viitanen, George L. Trainor, Soo S. Ko

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1999

Language:

english

File:

PDF, 181 KB

english, 1999

26

Design and selection of DMP 850 and DMP 851: the next generation of cyclic urea HIV protease inhibitors

James D. Rodgers, Patrick Y.S. Lam, Barry L. Johnson, Haisheng Wang, Soo S. Ko, Steven P. Seitz, George L. Trainor, Paul S. Anderson, Ronald M. Klabe, Lee T. Bacheler, Beverly Cordova, Sena Garber, Ca

Journal:

Chemistry & Biology

Year:

1998

Language:

english

File:

PDF, 2.46 MB

english, 1998

27

Design and selection of DMP 850 and DMP 851: the next generation of cyclic urea HIV protease inhibitors

James D. Rodgers, Patrick Y.S. Lam, Barry L. Johnson, Haisheng Wang, Soo S. Ko, Steven P. Seitz, George L. Trainor, Paul S. Anderson, Ronald M. Klabe, Lee T. Bacheler, Beverly Cordova, Sena Garber, Ca

Journal:

Chemistry & Biology

Year:

1998

File:

PDF, 33 KB

1998

28

An evaluation of the adequacy of health visitor education for neonatal hip screening

Pauline E Haugh, Carolyn Mason, Bernadette P Trainor, W George Kernohan, Kathryn Thompson, Raymond A B Mollan

Journal:

Journal of Advanced Nursing

Year:

1994

Language:

english

File:

PDF, 585 KB

english, 1994

29

Preface

George L. Trainor

Journal:

Perspectives in Drug Discovery and Design

Year:

1996

Language:

english

File:

PDF, 116 KB

english, 1996

30

Housing Choice and Control, Housing Quality, and Control over Professional Support as Contributors to the Subjective Quality of Life and Community Adaptation of People with Severe Mental Illness

Geoffrey Nelson, John Sylvestre, Tim Aubry, Lindsey George, John Trainor

Journal:

Administration and Policy in Mental Health and Mental Health Services Research

Year:

2007

Language:

english

File:

PDF, 151 KB

english, 2007

31

2,4-Disubstituted piperidines as selective CC chemokine receptor 3 (CCR3) antagonists: Synthesis and selectivity

Paul S. Watson, Bin Jiang, Kim Harrison, Nao Asakawa, Patricia K. Welch, Maryanne Covington, Nicole C. Stowell, Eric A. Wadman, Paul Davies, Kimberly A. Solomon, Robert C. Newton, George L. Trainor, S

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 131 KB

english, 2006

32

Introduction modified oligonucleotides

George L. Trainor

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1994

Language:

english

File:

PDF, 73 KB

english, 1994

33

The discovery of 4-(3-pentylamino)-2,7-dimethyl-8-(2-methyl-4-methoxyphenyl)-pyrazolo-[1,5-a]-pyrimidine: A corticotropin-releasing factor (hCRF1) antagonist

Paul J. Gilligan, Caryn Baldauf, Anthony Cocuzza, Dennis Chidester, Robert Zaczek, Lawrence W. Fitzgerald, John McElroy, Mark A. Smith, H.-S.L. Shen, Jo Anne Saye, David Christ, George Trainor, David

Journal:

Bioorganic & Medicinal Chemistry

Year:

2000

Language:

english

File:

PDF, 172 KB

english, 2000

34

Drug design with a new transition state analog of the hydrated carbonyl: silicon-based inhibitors of the HIV protease

Chien-An Chen, Scott McN Sieburth, Athanasios Glekas, Gregory W Hewitt, George L Trainor, Susan Erickson-Viitanen, Sena S Garber, Beverly Cordova, Susan Jeffry, Ronald M Klabe

Journal:

Chemistry & Biology

Year:

2001

Language:

english

File:

PDF, 328 KB

english, 2001

35

Preclinical antitumor activity of XK469 (NSC 656889)

Patricia M LoRusso, Ralph Parchment, Lisa Demchik, Juianna Knight, Lisa Polin, Janet Dzubow, Carl Behrens, Barbara Harrison, George Trainor, Thomas H. Corbett

Journal:

Investigational New Drugs

Year:

1998

Language:

english

File:

PDF, 108 KB

english, 1998

36

Selective inhibition of bacterial dihydroorotate dehydrogenases by thiadiazolidinediones

Jovita Marcinkeviciene, M.John Rogers, Lisa Kopcho, Wenjun Jiang, Kathy Wang, Dennis J Murphy, Jonathan Lippy, Steven Link, Thomas D.Y Chung, Frank Hobbs, Tasir Haque, George L Trainor, Andrew Slee, A

Journal:

Biochemical Pharmacology

Year:

2000

Language:

english

File:

PDF, 229 KB

english, 2000

37

High incidence of congenital dislocation of the hip in Northern Ireland

Christopher C. Patterson, W. George Kernohan, RAB Mollan, Pauline E. Haugh, Bernadette P. Trainor

Journal:

Paediatric and Perinatal Epidemiology

Year:

1995

Language:

english

File:

PDF, 450 KB

english, 1995

38

Nurses detecting infant hip abnormalities

Pauline Haugh, Bernadette P. Trainor, W. George Kernohan

Journal:

Journal of Orthopaedic Nursing

Year:

1997

Language:

english

File:

PDF, 467 KB

english, 1997

39

Discovery and Structure−Activity Relationship of N-(Ureidoalkyl)-Benzyl-Piperidines As Potent Small Molecule CC Chemokine Receptor-3 (CCR3) Antagonists

De Lucca, George V., Kim, Ui T., Johnson, Curt, Vargo, Brian J., Welch, Patricia K., Covington, Maryanne, Davies, Paul, Solomon, Kimberly A., Newton, Robert C., Trainor, George L., Decicco, Carl P., K

Journal:

Journal of Medicinal Chemistry

Year:

2002

Language:

english

File:

PDF, 202 KB

english, 2002

40

Cyclin-Dependent Kinase Inhibitors: Useful Targets in Cell Cycle Regulation

Sielecki, Thais M., Boylan, John F., Benfield, Pamela A., Trainor, George L.

Journal:

Journal of Medicinal Chemistry

Year:

2000

Language:

english

File:

PDF, 599 KB

english, 2000

41

Discovery of Pyrrolopyridine−Pyridone Based Inhibitors of Met Kinase: Synthesis, X-ray Crystallographic Analysis, and Biological Activities

Kim, Kyoung Soon, Zhang, Liping, Schmidt, Robert, Cai, Zhen-Wei, Wei, Donna, Williams, David K., Lombardo, Louis J., Trainor, George L., Xie, Dianlin, Zhang, Yaquan, An, Yongmi, Sack, John S., Tokarsk

Journal:

Journal of Medicinal Chemistry

Year:

2008

Language:

english

File:

PDF, 812 KB

english, 2008

42

High acylation rates and enantioselectivity with cyclodextrin complexes of rigid substrates

Trainor, George L., Breslow, Ronald

Journal:

Journal of the American Chemical Society

Year:

1981

Language:

english

File:

PDF, 761 KB

english, 1981

43

Synthesis, stability, and biological evaluation of water-soluble prodrugs of a new echinocandin lipopeptide. Discovery of a potential clinical agent for the treatment of systemic candidiasis and Pneumocystis carinii pneumonia (PCP)

Balkovec, James M., Black, Regina M., Hammond, Milton L., Heck, James V., Zambias, Robert A., Abruzzo, George, Bartizal, Ken, Kropp, Helmut, Trainor, Charlotte

Journal:

Journal of Medicinal Chemistry

Year:

1992

Language:

english

File:

PDF, 718 KB

english, 1992

44

Trends in Kinase Selectivity: Insights for Target Class-Focused Library Screening

Posy, Shana L., Hermsmeier, Mark A., Vaccaro, Wayne, Ott, Karl-Heinz, Todderud, Gordon, Lippy, Jonathan S., Trainor, George L., Loughney, Deborah A., Johnson, Stephen R.

Journal:

Journal of Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 6.71 MB

english, 2011

45

-Trifluoromethyl Carbohydrates

Trainor, George L.

Journal:

Journal of Carbohydrate Chemistry

Year:

1985

Language:

english

File:

PDF, 702 KB

english, 1985

46

[Annual Reports in Medicinal Chemistry] Annual Reports in Medicinal Chemistry Volume 42 Volume 42 || Chapter 31 Plasma Protein Binding and the Free Drug Principle: Recent Developments and Applications

Trainor, George L.

Year:

2007

Language:

english

File:

PDF, 138 KB

english, 2007

47

Modulation of cofilin phosphorylation by inhibition of the Lim family kinases

He, Liqi, Seitz, Steven P., Trainor, George L., Tortolani, David, Vaccaro, Wayne, Poss, Michael, Tarby, Christine M., Tokarski, John S., Penhallow, Becky, Hung, Chen-Yi, Attar, Ricardo, Lin, Tai-An

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 600 KB

english, 2012

48

[Part 2: Physical Sciences] || Evidence for the General Base Mechanism in Carboxypeptidase A-Catalyzed Reactions: Partitioning Studies on Nucleophiles and H218O Kinetic Isotope Effects

Ronald Breslow, Jik Chin, Donald Hilvert and George Trainor

Journal:

Proceedings of the National Academy of Sciences

Year:

1983

Language:

english

File:

PDF, 968 KB

english, 1983

49

Preparation of a stable (glucopyranosyl)iron compound

Trainor, George L., Smart, Bruce E.

Journal:

Journal of Organic Chemistry

Year:

1983

Language:

english

File:

PDF, 223 KB

english, 1983

50

DNA sequencing, automation, and the human genome

Trainor, George L.

Journal:

Analytical Chemistry

Year:

1990

Language:

english

File:

PDF, 3.40 MB

english, 1990